A Novel Benzopyrane Derivative Targeting Cancer Cell Metabolic and Survival Pathways
نویسندگان
چکیده
منابع مشابه
Targeting procaspase-3 with WF-208, a novel PAC-1 derivative, causes selective cancer cell apoptosis
Caspase-3 is a critical effector caspase in apoptosis cascade, and is often over-expressed in many cancer tissues. The first synthesized procaspase-3 activator, PAC-1, induces cancer cell apoptosis and exhibits antitumour activity in murine xenograft models. To identify more potent procaspase-3 activators, a series of compounds were designed, synthesized and evaluated for their ability of induc...
متن کاملMolecular Pathways Molecular Pathways: Targeting MYC-induced Metabolic Reprogramming and Oncogenic Stress in Cancer
MYC is amultifunctional transcription factor that is deregulated inmany human cancers. MYC impacts a collaborative genetic program that orchestrates cell proliferation, metabolism, and stress responses. Although the progression of MYC-amplified tumors shows robust dependence on MYC activity, directly targeting MYC as a therapeutic method has proven to be technically difficult. Therefore, altern...
متن کاملTargeting Energy Metabolic and Oncogenic Signaling Pathways in Triple-negative Breast Cancer by a Novel Ampk Activator
TARGETING ENERGY METABOLIC AND ONCOGENIC SIGNALING PATHWAYS IN TRIPLE-NEGATIVE BREAST CANCER BY A NOVEL AMPK ACTIVATOR Kuen-Haur Lee, En-Chi Hsu, Jih-Hwa Guh, Hsiao-Ching Yang, Dasheng Wang, Samuel K. Kulp, Charles L. Shapiro, and Ching-Shih Chen From Division of Medicinal Chemistry, College of Pharmacy, and Division of Medical Oncology, College of Medicine, The Ohio State University, Columbus,...
متن کاملtargeting gastric cancer stem cells through developmental pathways: hypothesis
cancer stem cells (cscs) have been defined as a unique subpopulation in tumors, endowed with the capacity to initiate tumor progression, maintain self-renewal as well as metastatic potential. recently, more evidence strongly indicates the existence of cscs in solid tumors of wide variety of organs such as breast, brain and stomach. recent studies suggest that a special subpopulation of gastric ...
متن کاملTargeting protein kinase CK2 suppresses bladder cancer cell survival via the glucose metabolic pathway
Casein kinase 2 (CK2) is a constitutively active serine/threonine kinase that promotes cell proliferation and resists apoptosis. Elevated CK2 expression has been demonstrated in several solid tumors. The expression of CK2α in bladder cancer was elevated in tumor tissues compared with that in adjacent normal tissues. Amplified expression of CK2α was highly correlated with histological grade in b...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancers
سال: 2021
ISSN: 2072-6694
DOI: 10.3390/cancers13112840